ABSTRACT
An association of unilateral pulmonary agenesis with in situ neuroblastoma of adrenal gland in a newborn having multiple congenital anomalies is being reported. Polycystic right kidney and absent left kidney, leading to severe oligohydramnios with secondary Potter's syndrome and Breech deformation sequence, were additional malformations present in our proposita.
Subject(s)
Abnormalities, Multiple/pathology , Adrenal Gland Neoplasms/pathology , Humans , Infant, Newborn , Infant, Premature , Infant, Very Low Birth Weight , Kidney/abnormalities , Lung/abnormalities , Male , Neuroblastoma/pathologyABSTRACT
A case of Limb body wall complex is reported in a preterm, Low birth weight and stillborn neonate. The proposita had abdominal wall defect with evisceration of the organs into an amnio-peritonial sac, a short body stalk, torsion of spine with scoliosis and limb defects. Unusual associations present in this case were absent thymus, interstitial calcification in kidney and a history of exposure to birth control pills during first two months post-conception.
Subject(s)
Abdominal Muscles/abnormalities , Abnormalities, Multiple , Adult , Contraceptives, Oral , Female , Fetal Death , Humans , Limb Deformities, Congenital/etiology , Maternal-Fetal Exchange , PregnancyABSTRACT
A rare case of sirenomelia in a LBW, IUGR & second of a dizygotic twin having multiple congenital anomalies is being reported. Apart from the features of sirenomelia, the newborn had a single umbilical artery, radial hypoplasia, total anorectal & urogenital agenesis and undetermined sex. The single umbilical artery had a normal origin from the iliac artery. There was no Vitelline arterial steal phenomenon. Theories put forward regarding etiopathogenesis are discussed. We conclude that the anomalies in the present case are difficult to be explained with earlier proposed theories. This puts an emphasis on reconsideration of old theory of genetic injury to the embryo by unknown factors.